Our Work
Our lab uses genomics, microbiology, and computational biology to apply bioinformatic and epidemiological methods to interpret complex pathogen data and create a better understanding of infectious diseases.
MRSA
The Guthrie Lab investigates genomic changes in MRSA to understand its evolving complexity. Using genomics, bioinformatics, and microbiology, we study transmission patterns, predict antimicrobial resistance, and track the evolution of Canadian strains. From a One Health perspective, we also consider how human, animal, and environmental reservoirs contribute to MRSA emergence and spread.
Mycobacteria
The Guthrie lab uses whole genome sequencing (WGS) to support the investigation of tuberculosis (TB) outbreaks and improve our understanding of transmission risk factors. As part of the Comprehensive Resistance Prediction for Tuberculosis: an International Consortium (CRyPTIC) the Guthrie lab is contributing to improved genetic prediction of resistance and understanding the underlying mechanisms of resistance. In addition to TB research we are also investigating nontuberculous mycobacteria infection and antimicrobial resistance using WGS and bioinformatics.
COVID-19
The Guthrie lab aims to further our understanding of the COVID-19 pandemic through genomic sequencing of SARS-CoV-2. Whole genome sequencing provides insight to risk factors for transmission and outbreaks.